摘要翻译：
在此，我们提出了一种在统一的概念和方法框架中结合结构-功能关系的生物结构鲁棒性方法，并设想了利用充分的计算和实验方法对其进行研究。为了将这种结构鲁棒性与系统抽象的组织鲁棒性区分开来，我们称之为anapedesis，并将其定义为生物对象（从生物分子到生物体）在变形和恢复的同时最小化和/或修复拉伸产生的损伤的尺度无关性质。我们建议研究生物物体变形的后果，更接近于它们的结构和/或功能失效，而不是以前认为相关的。我们指出，结构鲁棒性作为一个基本原则存在于生物医学的许多方面：许多病理状态可能源于分子、细胞及其高阶组装体无法保持对变形的鲁棒性。此外，结构鲁棒性可能是生物进化前和进化后的关键选择标准，其普遍性可以通过使用遗传算法建模来证明。因此，对生物结构鲁棒性的具体研究有助于解决生物学和医学的基本问题。
---
英文标题：
《Anapedesis: Implications and Applications of Bio-Structural Robustness》
---
作者：
Nicanor I. Moldovan
---
最新提交年份：
2008
---
分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
--
一级分类：Quantitative Biology        数量生物学
二级分类：Cell Behavior        细胞行为
分类描述：Cell-cell signaling and interaction; morphogenesis and development; apoptosis; bacterial conjugation; viral-host interaction; immunology
细胞-细胞信号传导及相互作用；形态发生和发育；细胞凋亡；细菌接合；病毒-宿主相互作用；免疫学
--

---
英文摘要：
  Here we develop an approach to bio-structural robustness integrated with structure-function relationship in a unified conceptual and methodological framework, and envision its study using adequate computational and experimental methods. To distinguish this structural robustness from the abstract organizational robustness of systems, we call it anapedesis, and define it as the scale-independent property of biological objects, from biomolecules to organisms, to deform and recover while minimizing and/or repairing the damage produced by stretch. We propose to study the consequences of deformation of biological objects closer to their structural and/or functional failure than previously considered relevant. We show that structural robustness is present as a basic principle in many facets of biomedicine: many pathological conditions may derive from the failure of molecules, cells and their higher-order assemblies to maintain robustness against deformation. Furthermore, structural robustness could have been the key selective criterion during pre-biotic evolution and afterwards, and its universality can be demonstrated by modeling using genetic algorithms. Thus, the specific investigation of bio-structural robustness as anapedesis could help the solving of fundamental problems of biology and medicine.
---
PDF链接：
https://arxiv.org/pdf/0806.0449