摘要翻译：
丰富的益生元进化信息仍然存储在当代基因组数据中。序列水平上的统计机制可能在益生元进化中发挥重要作用。通过对基因组序列的统计分析，发现遗传密码的进化与基因组的组织结构密切相关。根据密码子在益生元进化过程中的招募顺序，比较不同物种基因组中密码子的分布，构建了物种的生物多样性空间，证实了遗传密码的进化与生命树之间的密切关系。一方面，根据物种在生物多样性空间中的距离矩阵，可以重建生命的三域树，从而支持三域树而不是原始树。另一方面，通过比较64个密码子在基因组中的分布，可以得到密码子的进化树，这与路线图上密码子的招募顺序一致。这是一种研究后生动物起源、灵长类进化等的简单系统基因组学方法，该研究应视为在益生元序列进化中用统计机制解释生命三域多样化的探索性尝试。结果表明，三重密码子中碱基的数目可以用三重DNA链的数目来解释。生命对不断变化的环境的适应可能是由于序列水平上冗余基因组的组装。
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英文标题：
《Observations and perspectives on the diversification of genomes》
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作者：
Dirson Jian Li
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最新提交年份：
2018
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Rich information on the prebiotic evolution is still stored in contemporary genomic data. The statistical mechanism at the sequence level may play a significant role in the prebiotic evolution. Based on statistical analysis of genome sequences, it has been observed that there is a close relationship between the evolution of the genetic code and the organisation of genomes. A biodiversity space for species is constructed based on comparing the distributions of codons in genomes for different species according to recruitment order of codons in the prebiotic evolution, by which a closely relationship between the evolution of the genetic code and the tree of life has been confirmed. On one hand, the three domain tree of life can be reconstructed according to the distance matrix of species in this biodiversity space, which supports the three-domain tree rather than the eocyte tree. On the other hand, an evolutionary tree of codons can be obtained by comparing the distributions of the 64 codons in genomes, which agrees with the recruitment order of codons on the roadmap. This is a simple phylogenomic method to study the origins of metazoan, the evolution of primates, etc. This study should be regarded as an exploratory attempt to explain the diversification of the three domains of life by statistical mechanism in prebiotic sequence evolution. It is indicated that the number of bases in the triplet codons might be explained statistically by the number of strands in the triplex DNAs. The adaptation of life to the changing environment might be due to assembly of redundant genomes at the sequence level.
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PDF链接：
https://arxiv.org/pdf/1807.03784