摘要翻译：
在这项数值研究中，我们利用详细的Luo-Rudy动力学模型，研究了由于M细胞引起的心脏组织内在异质性在折返性兴奋产生和维持中的作用。该模型已被扩展到包括长QT3综合征的描述，并在一维（对应于穿过心室壁的电缆）和二维（代表跨壁切片）中进行研究。我们集中讨论了两种可能的产生可重入事件的机制。我们首先研究发生在M细胞中的早期后去极化是否能引发再入。我们发现，即使在长QT强度较大的情况下，相邻细胞之间的电性耦合也阻止了早期后去极化产生折返。然后，我们研究M细胞结构域，其缓慢的复极，是否可以作为过早刺激的波块。我们发现包含一个M细胞结构域在某些情况下可以导致折返性兴奋，我们确定折返性兴奋的寿命是结构域的大小和几何形状以及长QT综合征强度的函数。
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英文标题：
《The role of M cells and the long QT syndrome in cardiac arrhythmias:
  simulation studies of reentrant excitations using a detailed
  electrophysiological model》
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作者：
Herv\'e Henry and Wouter-Jan Rappel
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最新提交年份：
2004
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Tissues and Organs        组织器官
分类描述：Blood flow in vessels, biomechanics of bones, electrical waves, endocrine system, tumor growth
血管内血流，骨骼生物力学，电波，内分泌系统，肿瘤生长
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一级分类：Physics        物理学
二级分类：Other Condensed Matter        其他凝聚态物质
分类描述：Work in condensed matter that does not fit into the other cond-mat classifications
在不适合其他cond-mat分类的凝聚态物质中工作
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一级分类：Physics        物理学
二级分类：Pattern Formation and Solitons        图形形成与孤子
分类描述：Pattern formation, coherent structures, solitons
图案形成，相干结构，孤子
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一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  In this numerical study, we investigate the role of intrinsic heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using the detailed Luo-Rudy dynamic model. This model has been extended to include a description of the long QT 3 syndrome, and is studied in both one dimension, corresponding to a cable traversing the ventricular wall, and two dimensions, representing a transmural slice. We focus on two possible mechanisms for the generation of reentrant events. We first investigate if early-after-depolarizations occurring in M cells can initiate reentry. We find that, even for large values of the long QT strength, the electrotonic coupling between neighboring cells prevents early-after-depolarizations from creating a reentry. We then study whether M cell domains, with their slow repolarization, can function as wave blocks for premature stimuli. We find that the inclusion of an M cell domain can result in some cases in reentrant excitations and we determine the lifetime of the reentry as a function of the size and geometry of the domain and of the strength of the long QT syndrome.
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PDF链接：
https://arxiv.org/pdf/q-bio/0407027