摘要翻译:
突变通常根据其对核苷酸序列的影响和大小进行分类。在这里,我们认为,如果我们的主要目的是了解突变对进化结果(如适应或物种形成)的影响,我们需要考虑它们的群体遗传和基因组效应,从改变重组率到改变染色质。我们首先回顾不同突变类型的已知群体遗传和基因组效应,并将这些与漂移和选择的主要进化过程联系起来。我们说明了突变类型是如何与进化结果联系起来的,并为进一步探索和量化这些关系提供了建议。这种重构为确定不同突变类型的进化意义奠定了基础。
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英文标题:
《Unboxing mutations: Connecting mutation types with evolutionary
consequences》
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作者:
Emma L. Berdan, Alexandre Blanckaert, Tanja Slotte, Alexander Suh,
Anja M. Westram, In\^es Fragata
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最新提交年份:
2020
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
Mutations are typically classified by their effects on the nucleotide sequence and by their size. Here, we argue that if our main aim is to understand the effect of mutations on evolutionary outcomes (such as adaptation or speciation), we need to instead consider their population genetic and genomic effects, from altering recombination rate to modifying chromatin. We start by reviewing known population genetic and genomic effects of different mutation types and connect these to the major evolutionary processes of drift and selection. We illustrate how mutation type can thus be linked with evolutionary outcomes and provide suggestions for further exploring and quantifying these relationships. This reframing lays a foundation for determining the evolutionary significance of different mutation types.
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PDF链接:
https://arxiv.org/pdf/2009.13830