摘要翻译:
睡眠是发生在多细胞动物中最值得注意和广泛的现象之一。然而,对于其起源的理论还没有达成共识。特别是,没有明确的定量理论来解释或区分无数关于睡眠的假说。在这里,我们发展了一个关于哺乳动物睡眠的一般定量理论,它将许多基本参数与新陈代谢率和体型联系起来。大多数关于睡眠功能的机制都可以放在这个框架中,例如,细胞修复代谢过程造成的损伤和皮质重组来处理感觉输入。我们的理论导致了睡眠时间、睡眠周期时间和快速眼动时间作为身体和大脑质量的函数的预测,并解释了,例如,为什么老鼠每天睡14个小时,而大象每天睡3.5个小时。96种哺乳动物的数据,跨越6个数量级的身体大小,与这些预测一致,并提供了强有力的证据,表明睡眠的时间尺度是由大脑而不是整个身体的新陈代谢率设定的。
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英文标题:
《Towards a Quantitative, Metabolic Theory for Mammalian Sleep》
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作者:
Van M. Savage and Geoffrey B. West
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最新提交年份:
2005
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
Sleep is one of the most noticeable and widespread phenomena occurring in multicellular animals. Nevertheless, no consensus for a theory of its origins has emerged. In particular, no explicit, quantitative theory exists that elucidates or distinguishes between the myriad hypotheses proposed for sleep. Here, we develop a general, quantitative theory for mammalian sleep that relates many of its fundamental parameters to metabolic rate and body size. Most mechanisms suggested for the function of sleep can be placed in this framework, e.g., cellular repair of damage caused by metabolic processes and cortical reorganization to process sensory input. Our theory leads to predictions for sleep time, sleep cycle time, and REM (rapid-eye-movement) time as functions of body and brain mass, and explains, for example, why mice sleep \~14 hours per day relative to the 3.5 hours per day that elephants sleep. Data for 96 species of mammals, spanning six orders of magnitude in body size, are consistent with these predictions and provide strong evidence that time scales for sleep are set by the brain's, not the whole-body, metabolic rate.
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PDF链接:
https://arxiv.org/pdf/q-bio/0506042