摘要翻译:
分子马达是利用某种形式的输入能量进行机械功的大分子复合体。这些马达在其上运动的丝状轨道由蛋白质(如微管)或核酸(DNA或RNA)组成。通常,许多这样的电机在同一轨道上同时运动,它们的集体性质与高速公路上的车辆交通有表面上的相似之处。我们开发的模型提供了“统一”的描述:在低密度极限下,一个模型捕捉单个马达的输运性质,而在高密度下,同一模型解释相互作用马达的集体时空组织。通过与车辆交通的类比,我们引入了新的量来表征分子马达在其轨道上的时空组织的性质。我们展示了交通样的细胞内集体现象如何依赖于相应的单个马达的机械化学。
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英文标题:
《Intra-cellular traffic: bio-molecular motors on filamentary tracks》
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作者:
Debashish Chowdhury, Aakash Basu, Ashok Garai, Philip Greulich,
Katsuhiro Nishinari, Andreas Schadschneider and Tripti Tripathi
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最新提交年份:
2008
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分类信息:
一级分类:Physics 物理学
二级分类:Biological Physics 生物物理学
分类描述:Molecular biophysics, cellular biophysics, neurological biophysics, membrane biophysics, single-molecule biophysics, ecological biophysics, quantum phenomena in biological systems (quantum biophysics), theoretical biophysics, molecular dynamics/modeling and simulation, game theory, biomechanics, bioinformatics, microorganisms, virology, evolution, biophysical methods.
分子生物物理、细胞生物物理、神经生物物理、膜生物物理、单分子生物物理、生态生物物理、生物系统中的量子现象(量子生物物理)、理论生物物理、分子动力学/建模与模拟、博弈论、生物力学、生物信息学、微生物、病毒学、进化论、生物物理方法。
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一级分类:Physics 物理学
二级分类:Statistical Mechanics 统计力学
分类描述:Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变,热力学,场论,非平衡现象,重整化群和标度,可积模型,湍流
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一级分类:Quantitative Biology 数量生物学
二级分类:Subcellular Processes 亚细胞过程
分类描述:Assembly and control of subcellular structures (channels, organelles, cytoskeletons, capsules, etc.); molecular motors, transport, subcellular localization; mitosis and meiosis
亚细胞结构(通道、细胞器、细胞骨架、囊膜等)的组装和控制;分子马达;转运;亚细胞定位;有丝分裂和减数分裂
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英文摘要:
Molecular motors are macromolecular complexes which use some form of input energy to perform mechanical work. The filamentary tracks, on which these motors move, are made of either proteins (e.g., microtubules) or nucleic acids (DNA or RNA). Often, many such motors move simultaneously on the same track and their collective properties have superficial similarities with vehicular traffic on highways. The models we have developed provide ``unified'' description: in the low-density limit, a model captures the transport properties of a single motor while, at higher densities the same model accounts for the collective spatio-temporal organization of interacting motors. By drawing analogy with vehicular traffic, we have introduced novel quantities for characterizing the nature of the spatio-temporal organization of molecular motors on their tracks. We show how the traffic-like intracellular collective phenomena depend on the mechano-chemistry of the corresponding individual motors.
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PDF链接:
https://arxiv.org/pdf/801.2214