摘要翻译:
实验表明,真核细胞的运动是由细胞膜上两种竞争酶的相分离过程调节的,这种相分离过程有效地放大了化学引诱剂的浅外部梯度。值得注意的是,细胞能够自我调节最终的酶浓度到相共存的平衡状态,对于广泛的平均引诱剂浓度。我们提出了一个简单的晶格模型,在这个模型中,除了酶之间的短程吸引之外,还自然地产生了物理上的长程排斥,这很容易解释这种观察到的行为。
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英文标题:
《Spatial signal amplification in cell biology: a lattice-gas model for
self-tuned phase ordering》
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作者:
Teresa Ferraro, Antonio de Candia, Andrea Gamba, Antonio Coniglio
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最新提交年份:
2007
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分类信息:
一级分类:Physics 物理学
二级分类:Statistical Mechanics 统计力学
分类描述:Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变,热力学,场论,非平衡现象,重整化群和标度,可积模型,湍流
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一级分类:Quantitative Biology 数量生物学
二级分类:Cell Behavior 细胞行为
分类描述:Cell-cell signaling and interaction; morphogenesis and development; apoptosis; bacterial conjugation; viral-host interaction; immunology
细胞-细胞信号传导及相互作用;形态发生和发育;细胞凋亡;细菌接合;病毒-宿主相互作用;免疫学
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英文摘要:
Experiments show that the movement of eukaryotic cells is regulated by a process of phase separation of two competing enzymes on the cell membrane, that effectively amplifies shallow external gradients of chemical attractant. Notably, the cell is able to self-tune the final enzyme concentrations to an equilibrium state of phase coexistence, for a wide range of the average attractant concentration. We propose a simple lattice model in which, together with a short-range attraction between enzymes, a long-range repulsion naturally arises from physical considerations, that easily explains such observed behavior.
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PDF链接:
https://arxiv.org/pdf/711.309