David G. Kleinbaum

Mitchel Klein

A Self-Learning Text

Third Edition

Chapter 1 Introduction to Survival Analysis 1

Introduction 2

Abbreviated Outline 2

Objectives 3

Presentation 4

Detailed Outline 44

Practice Exercises 50

Test 52

Answers to Practice Exercises 54

Chapter 2 Kaplan-Meier Survival Curves

and the Log-Rank Test 55

Introduction 56

Abbreviated Outline 56

Objectives 57

Presentation 58

Detailed Outline 83

Practice Exercises 87

Test 91

Answers to Practice Exercises 93

Chapter 3 The Cox Proportional Hazards

Model and Its Characteristics 97

Introduction 98

Abbreviated Outline 98

Objectives 99

Presentation 100

Detailed Outline 145

Practice Exercises 149

Test 153

Answers to Practice Exercises 157

Chapter 4 Evaluating the Proportional Hazards

Assumption 161

Introduction 162

Abbreviated Outline 162

Objectives 163

Presentation 164

Detailed Outline 188

Practice Exercises 191

Test 194

Answers to Practice Exercises 197

Chapter 5 The Stratified Cox Procedure 201

Introduction 202

Abbreviated Outline 202

Objectives 203

Presentation 204

Detailed Outline 228

Practice Exercises 231

Test 234

Answers to Practice Exercises 237

Chapter 6 Extension of the Cox Proportional

Hazards Model for Time-Dependent

Variables 241

Introduction 242

Abbreviated Outline 242

Objectives 243

Presentation 244

Detailed Outline 278

Practice Exercises 281

Test 285

Answers to Practice Exercises 287

Chapter 7 Parametric Survival Models 289

Introduction 290

Abbreviated Outline 290

Objectives 291

Presentation 292

Detailed Outline 345

Practice Exercises 351

Test 356

Answers to Practice Exercises 359

Chapter 8 Recurrent Event Survival Analysis 363

Introduction 364

Abbreviated Outline 364

Objectives 365

Presentation 366

Detailed Outline 402

Practice Exercises 408

Test 412

Answers to Practice Exercises 422

Chapter 9 Competing Risks Survival Analysis 425

Introduction 426

Abbreviated Outline 428

Objectives 429

Presentation 430

Detailed Outline 474

Practice Exercises 481

Test 486

Answers to Practice Exercises 492

Chapter 10 Design Issues for Randomized Trials 497

Introduction 498

Abbreviated Outline 498

Objectives 499

Presentation 500

Detailed Outline 518

Practice Exercises 521

Test 523

Answers to Practice Exercises 523

Computer Appendix: Survival Analysis

on the Computer 525

A. Stata 527

B. SAS 570

C. SPSS 607

D. R Software 620