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2022-03-03
摘要翻译:
目前对生物现象的看法是基于生物分子范式,即生物有机体的发展完全是由以分子形式储存的信息定义的,这些信息是某种遗传密码。然而,新的事实和发现表明,生物现象不能仅归结为生物分子领域,还受其他自然机制的控制。这些机制与生物化学机制紧密合作,决定了个体有机体的生命周期,并由此决定了生物世界的起源和进化。在这里,我们提出了这样一个物理机制(一般生长规律),它代表了作用于细胞、器官、系统和整个生物水平的新的自然物理规律,与生物分子机制一起指导生长和繁殖。它对生物量生产和维持之间营养物质的分配施加了唯一定义的约束,从而定义了生物生命周期中生化反应的组成、它们的变化和不可逆性。在数学上,这个定律用增长方程来表示。利用这个方程,我们介绍了单细胞生物的生长模型,并解释了单细胞生物的分裂机制。所得结果对实验的高度充分性证明了一般生长规律和基于该规律的新的生命物理范式的有效性。
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英文标题:
《Physical paradigm of Life as a generalization of biochemical conception.
  A Physical law governing life origin and development》
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作者:
Yuri K. Shestopaloff
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最新提交年份:
2018
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分类信息:

一级分类:Quantitative Biology        数量生物学
二级分类:Other Quantitative Biology        其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
  The present view of biological phenomena is based on a biomolecular paradigm that development of living organisms is entirely defined by information stored in a molecular form as some genetic code. However, new facts and discoveries indicate that biological phenomena cannot be reduced to a biomolecular realm alone, but are also governed by mechanisms of other nature. These mechanisms, acting in tight cooperation with biochemical mechanisms, define life cycles of individual organisms, and, through this, the origin and evolution of the living world. Here, we present such a physical mechanism (General growth law), which represents a new physical law of nature acting at cellular, organ, system and whole organism levels, directing growth and reproduction together with biomolecular mechanisms. It imposes uniquely defined constraints on distribution of nutrients between biomass production and maintenance, thus defining the composition of biochemical reactions, their change and irreversibility during the organismal life cycle. Mathematically, this law is represented by the growth equation. Using this equation, we introduce growth models and explain division mechanisms for unicellular organisms. High adequacy of obtained results to experiments proves validity of the General growth law and of the new physical paradigm of Life based on this law.
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PDF链接:
https://arxiv.org/pdf/1609.09421
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