摘要翻译：
生物化学途径产生于不同类型的生物大分子在不同的细胞室和高粘性的胞浆中的一系列布朗碰撞。生化网络的功能表明，这种偶然的碰撞作为一个整体，导致了一个完美的同步秩序。然而，由于布朗碰撞的本质，当这种同步不能一致地出现时，一个小而非微不足道的概率总是与事件相关联；导致了生化途径的破坏。然后，系统的修复机制试图最大限度地减少损害，以恢复反应物浓度之间的适当同步水平。目前的工作提出了一个预测概率模型，描述了这一复杂和耦合的过程（损坏和修复）的各个方面。通过用Chapman-Kolmogorov方程描述Brownian碰撞的细胞质现实，该模型给出了对以下问题的解析答案：在任意时间间隔内，任何路径的片段以多大概率遭受损伤？在任意的时间间隔内，以多大的概率修复路径的损伤？
---
英文标题：
《A probabilistic model to describe the dual phenomena of biochemical
  pathway damage and biochemical pathway repair》
---
作者：
Anirban Banerji
---
最新提交年份：
2014
---
分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
--

---
英文摘要：
  Biochemical pathways emerge from a series of Brownian collisions between various types of biological macromolecules within separate cellular compartments and in highly viscous cytosol. Functioning of biochemical networks suggests that such serendipitous collisions, as a whole, result into a perfect synchronous order. Nonetheless, owing to the very nature of Brownian collisions, a small yet non-trivial probability can always be associated with the events when such synchronizations fail to emerge consistently; which account for a damage of a biochemical pathway. The repair mechanism of the system then attempts to minimize the damage, in the pursuit to bring restore the appropriate level of synchronization between reactant concentrations. Present work presents a predictive probabilistic model that describes the various facets of this complicated and coupled process(damaging and repairing). By describing the cytosolic reality of Brownian collisions with Chapman-Kolmogorov equations, the model presents analytical answers to the questions, with what probability a fragment of any pathway may suffer damage within an arbitrary interval of time? and with what probability the damage to a pathway can be repaired within any arbitrary interval of time?
---
PDF链接：
https://arxiv.org/pdf/1404.0701