摘要翻译：
我们通过细胞磷酸酶的调节，对受体激活的MAP激酶信号转导进行了数学模拟。激活诱导了与MAP激酶通路平行的磷酸酶级联。因此产生了一个新的调节基序，提供了对每个MAPK中间体的组合控制。这保证了信号传输的非线性模式，输出通过输入信号的强度和沿磷酸酶轴的活性梯度之间的平衡而成形。这种平衡的移动产生了基序拓扑结构的调制，从而扩大了输出响应的范围。因此，我们确定了信号处理的一个额外维度，其中对外部刺激的输出反应通过定义细胞表型状态的指标进行额外的过滤。
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英文标题：
《Integration of a Phosphatase Cascade with the MAP Kinase Pathway
  provides for a Novel Signal Processing Function》
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作者：
Virendra K. Chaudhri, Dhiraj Kumar, Manjari Misra, Raina Dua and
  Kanury V.S. Rao
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最新提交年份：
2009
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Molecular Networks        分子网络
分类描述：Gene regulation, signal transduction, proteomics, metabolomics, gene and enzymatic networks
基因调控、信号转导、蛋白质组学、代谢组学、基因和酶网络
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一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway. A novel regulatory motif was thus generated, providing for the combinatorial control of each MAPK intermediate. This ensured a non-linear mode of signal transmission with the output being shaped by the balance between the strength of input signal, and the activity gradient along the phosphatase axis. Shifts in this balance yielded modulations in topology of the motif, thereby expanding the repertoire of output responses. Thus we identify an added dimension to signal processing, wherein the output response to an external stimulus is additionally filtered through indicators that define the phenotypic status of the cell.
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PDF链接：
https://arxiv.org/pdf/0908.1515