摘要翻译:
与行为相关的神经活动模式发生在从原子分子到整个大脑的时间和空间的许多尺度上。在这里,我们通过使用物理学家设计的工具来分析其他科学领域的可比层次结构,探索在多体物理学的背景下解释神经生理学数据的可行性。我们关注的是一个介观层面,它提供了一个在神经元的微观功能和由血流动力学成像揭示的大脑系统的宏观功能之间的多步通路。我们使用高密度电极阵列收集的脑电图(EEG)记录,这些电极阵列固定在兔和猫的初级感觉区和边缘区的硬膜外表面,训练它们以不同的方式辨别条件刺激(CS)。Hilbert变换的脑电信号具有较高的时间分辨率,证明了载波的幅度(AM)和相位调制(PM)的不同间歇性空间模式,这些模式在近零时滞远距离内重复地在β和γ范围内重新同步。由于有限的传播速度,轴突突触传递的神经相互作用的主要机制应该在脑电振荡中施加距离依赖的延迟。它没有。相反,EEGs显示了异常色散的证据:在神经群体中存在低速的信息和能量转移范围,而高速的相变扩展范围。这种区别给现象贴上了标签,但没有解释它。在这篇报道中,我们利用能量耗散、皮层维持与AM模式相对应的多个基态以及序列中单个态的自发对称性击穿(SBS)排他性选择等概念对这些现象进行了分析。
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英文标题:
《Nonlinear brain dynamics as macroscopic manifestation of underlying
many-body field dynamics》
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作者:
Walter J. Freeman (2) and Giuseppe Vitiello (2) ((1) Department of
Molecular and Cell Biology, University of California, Berkeley CA, USA (2)
Dipartimento di Fisica ``E.R. Caianiello'', and INFN, Universita' degli Studi
di Salerno, Salerno, Italia)
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最新提交年份:
2005
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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一级分类:Physics 物理学
二级分类:Quantum Physics 量子物理学
分类描述:Description coming soon
描述即将到来
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英文摘要:
Neural activity patterns related to behavior occur at many scales in time and space from the atomic and molecular to the whole brain. Here we explore the feasibility of interpreting neurophysiological data in the context of many-body physics by using tools that physicists have devised to analyze comparable hierarchies in other fields of science. We focus on a mesoscopic level that offers a multi-step pathway between the microscopic functions of neurons and the macroscopic functions of brain systems revealed by hemodynamic imaging. We use electroencephalographic (EEG) records collected from high-density electrode arrays fixed on the epidural surfaces of primary sensory and limbic areas in rabbits and cats trained to discriminate conditioned stimuli (CS) in the various modalities. High temporal resolution of EEG signals with the Hilbert transform gives evidence for diverse intermittent spatial patterns of amplitude (AM) and phase modulations (PM) of carrier waves that repeatedly re-synchronize in the beta and gamma ranges at near zero time lags over long distances. The dominant mechanism for neural interactions by axodendritic synaptic transmission should impose distance-dependent delays on the EEG oscillations owing to finite propagation velocities. It does not. EEGs instead show evidence for anomalous dispersion: the existence in neural populations of a low velocity range of information and energy transfers, and a high velocity range of the spread of phase transitions. This distinction labels the phenomenon but does not explain it. In this report we explore the analysis of these phenomena using concepts of energy dissipation, the maintenance by cortex of multiple ground states corresponding to AM patterns, and the exclusive selection by spontaneous breakdown of symmetry (SBS) of single states in sequences.
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PDF链接:
https://arxiv.org/pdf/q-bio/0511037