摘要翻译：
利用精确可解的一维离散状态随机模型，从理论上研究了分子跨膜通道的输运。分子与膜孔之间的相互作用是通过一组不同能量的结合位点来模拟的。结果表明，相互作用势对粒子电流和易位分子数的涨落有很强的影响。对于小浓度梯度，吸引位导致最大的电流和涨落，而对于大浓度梯度，排斥位产生最大的通量和弥散。导致最大电流和最大涨落的相互作用能仅对局部对称势相同，而对局部非对称势不同。讨论了电流最大、离散最小的最优易位输运条件。在这种情况下，相互作用强度与平均力势的局部对称性无关。此外，本文还研究了相互作用势的全局不对称性对质点易位动力学的影响，结果表明，相互作用势的全局不对称性对质点易位动力学也有很强的影响。这些现象可以通过分析粒子进出通道中结合位点的细节来解释。
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英文标题：
《Effect of Interactions on Molecular Fluxes and Fluctuations in the
  Transport Across Membrane Channels》
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作者：
Anatoly B. Kolomeisky and Stanislav Kotsev
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最新提交年份：
2007
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分类信息：

一级分类：Physics        物理学
二级分类：Soft Condensed Matter        软凝聚态物质
分类描述：Membranes, polymers, liquid crystals, glasses, colloids, granular matter
膜，聚合物，液晶，玻璃，胶体，颗粒物质
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一级分类：Physics        物理学
二级分类：Statistical Mechanics        统计力学
分类描述：Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变，热力学，场论，非平衡现象，重整化群和标度，可积模型，湍流
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英文摘要：
  Transport of molecules across membrane channels is investigated theoretically using exactly solvable one-dimensional discrete-state stochastic models. An interaction between molecules and membrane pores is modeled via a set of binding sites with different energies. It is shown that the interaction potential strongly influences the particle currents as well as fluctuations in the number of translocated molecules. For small concentration gradients the attractive sites lead to largest currents and fluctuations, while the repulsive interactions yield the largest fluxes and dispersions for large concentration gradients. Interaction energies that lead to maximal currents and maximal fluctuations are the same only for locally symmetric potentials, while they differ for the locally asymmetric potentials. The conditions for the most optimal translocation transport with maximal current and minimal dispersion are discussed. It is argued that in this case the interaction strength is independent of local symmetry of the potential of mean forces. In addition, the effect of the global asymmetry of the interaction potential is investigated, and it is shown that it also strongly affects the particle translocation dynamics. These phenomena can be explained by analyzing the details of the particle entering and leaving the binding sites in the channel.
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PDF链接：
https://arxiv.org/pdf/710.4359