摘要翻译：
轴突引导是中枢神经系统和外周神经系统生长的关键过程。本研究采用多种系统生物学工具，对3种轴突引导相关疾病，即Duane回缩综合征(DRS)、水平注视性瘫痪伴进行性脊柱侧凸(HGPPS)和先天性眼外肌3型纤维化(CFEOM3)进行了研究，以确定与它们相关的基因和蛋白，从而更好地了解其潜在的分子机制包括调控机制。根据所进行的分析，从PPI网络中确定了7个重要的模块。已发现5种途径/过程与DRS、HGPPS和CFEOM3相关基因显著相关。从PPI网络中，已鉴定出3个hub蛋白-DRD2、UBC和CUL3。
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英文标题：
《Identification of Key Proteins Involved in Axon Guidance Related
  Disorders: A Systems Biology Approach》
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作者：
Ishtiaque Ahammad
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最新提交年份：
2018
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Axon guidance is a crucial process for growth of the central and peripheral nervous systems. In this study, 3 axon guidance related disorders, namely- Duane Retraction Syndrome (DRS) , Horizontal Gaze Palsy with Progressive Scoliosis (HGPPS) and Congenital fibrosis of the extraocular muscles type 3 (CFEOM3) were studied using various Systems Biology tools to identify the genes and proteins involved with them to get a better idea about the underlying molecular mechanisms including the regulatory mechanisms. Based on the analyses carried out, 7 significant modules have been identified from the PPI network. Five pathways/processes have been found to be significantly associated with DRS, HGPPS and CFEOM3 associated genes. From the PPI network, 3 have been identified as hub proteins- DRD2, UBC and CUL3.
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PDF链接：
https://arxiv.org/pdf/1805.01011