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2022-03-05
摘要翻译:
金纳米粒子在肿瘤诊断和治疗中显示出很大的应用前景,但由于其体积大,不能被代谢,更易在肝脾中积聚。小尺寸金纳米团簇可以穿透肾组织,通过肾脏清除降低体内毒性。在这项工作中,我们探讨了BSA和GSH保护的金纳米簇24小时和28天的体内肾脏清除率、生物分布和毒性反应。BSA保护的金纳米簇具有较低的肾脏清除率,仅能清除1%的金,而GSH保护的金纳米簇具有较高的肾脏清除率,在24h后可清除36%的金。生物分布进一步表明,GSH保护的纳米簇可代谢94%的金,而BSA保护的纳米簇在28天后仅能代谢不到5%的金。GSH和BSA保护的金纳米簇在24小时后都会引起急性感染、炎症和肾功能损害,但GSH保护的金纳米簇在28天后可消除这些毒性反应。两种金纳米簇也可影响免疫系统,但对GSH保护的金纳米簇的免疫应答在28天后也可恢复。这些发现表明GSH保护的纳米金团簇体积小,可通过肾脏清除代谢,从而显著降低毒性。但BSA保护的金纳米簇可形成大的化合物,并进一步在肝脏和脾脏中积累,引起不可修复的毒性反应。因此,GSH保护的金纳米簇在体内成像和治疗方面具有很大的潜力,而BSA保护的金纳米簇可以作为肝癌治疗的药物。
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英文标题:
《In Vivo Renal Clearance, Biodistribution, Toxicity of Gold nanoclusters》
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作者:
Xiao-Dong Zhang, Di Wu, Xiu Shen, Pei-Xun Liu, Fei-Yue Fan, and
  Sai-Jun Fan
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最新提交年份:
2012
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分类信息:

一级分类:Physics        物理学
二级分类:Medical Physics        医学物理学
分类描述:Radiation therapy. Radiation dosimetry. Biomedical imaging modelling.  Reconstruction, processing, and analysis. Biomedical system modelling and analysis. Health physics. New imaging or therapy modalities.
放射治疗。辐射剂量学。生物医学成像建模。重建、处理和分析。生物医学系统建模与分析。健康物理学。新的成像或治疗方式。
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一级分类:Physics        物理学
二级分类:Biological Physics        生物物理学
分类描述:Molecular biophysics, cellular biophysics, neurological biophysics, membrane biophysics, single-molecule biophysics, ecological biophysics, quantum phenomena in biological systems (quantum biophysics), theoretical biophysics, molecular dynamics/modeling and simulation, game theory, biomechanics, bioinformatics, microorganisms, virology, evolution, biophysical methods.
分子生物物理、细胞生物物理、神经生物物理、膜生物物理、单分子生物物理、生态生物物理、生物系统中的量子现象(量子生物物理)、理论生物物理、分子动力学/建模与模拟、博弈论、生物力学、生物信息学、微生物、病毒学、进化论、生物物理方法。
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一级分类:Quantitative Biology        数量生物学
二级分类:Other Quantitative Biology        其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
  Gold nanoparticles have shown great prospective in cancer diagnosis and therapy, but they can not be metabolized and prefer to accumulate in liver and spleen due to their large size. The gold nanoclusters with small size can penetrate kidney tissue and have promise to decrease in vivo toxicity by renal clearance. In this work, we explore the in vivo renal clearance, biodistribution, and toxicity responses of the BSA- and GSH-protected gold nanoclusters for 24 hours and 28 days. The BSA-protected gold nanoclusters have low-efficient renal clearance and only 1% of gold can be cleared, but the GSH-protected gold nanoclusters have high-efficient renal clearance and 36 % of gold can be cleared after 24 hours. The biodistribution further reveals that 94% of gold can be metabolized for the GSH-protected nanoclusters, but only less than 5% of gold can be metabolized for the BSA-protected nanoclusters after 28 days. Both of the GSH- and BSA-protected gold nanoclusters cause acute infection, inflammation, and kidney function damage after 24 hours, but these toxicity responses for the GSH-protected gold nanoclusters can be eliminated after 28 days. Immune system can also be affected by the two kinds of gold nanoclusters, but the immune response for the GSH-protected gold nanoclusters can also be recovered after 28 days. These findings show that the GSH-protected gold nanoclusters have small size and can be metabolized by renal clearance and thus the toxicity can be significantly decreased. The BSA- protected gold nanoclusters, however, can form large compounds and further accumulate in liver and spleen which can cause irreparable toxicity response. Therefore, the GSH-protected gold nanoclusters have great potential for in vivo imaging and therapy, and the BSA-protected gold nanoclusters can be used as the agent of liver cancer therapy.
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PDF链接:
https://arxiv.org/pdf/1210.0037
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