摘要翻译：
提出了遗传密码构建和进化的定量理论。通过引入变异劣化(MD)的概念，建立了MD最小化的理论形式，证明了：1.遗传密码中密码子的冗余分布服从MD最小化原理；2、氨基酸在编码表上的亲水-疏水分布为全局MD(GMD)最小；3.由GMD的自适应最小化推导出标准遗传密码；4、标准遗传密码的变异可以用GMD形式进行定量解释，进化的总趋势是GMD不增加，这反映了对编码的选择。我们证明了编码中密码子的冗余分布和氨基酸的疏水-亲水（H-P）分布相对于突变参数是稳健的，并表明GMD可以看作是自适应景观上的一个非适应度函数。最后，研究了密码结构对称性的一个重要方面--阴阳对偶性。密码子之间的阴阳二重性为理解遗传密码中的H-P结构提供了坚实的基础。
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英文标题：
《A Unified Theory on Construction and Evolution of the Genetic Code》
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作者：
Liaofu Luo
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最新提交年份：
2009
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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一级分类：Quantitative Biology        数量生物学
二级分类：Genomics        基因组学
分类描述：DNA sequencing and assembly; gene and motif finding; RNA editing and alternative splicing; genomic structure and processes (replication, transcription, methylation, etc); mutational processes.
DNA测序与组装；基因和基序的发现；RNA编辑和选择性剪接；基因组结构和过程（复制、转录、甲基化等）；突变过程。
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英文摘要：
  A quantitative theory on the construction and the evolution of the genetic code is proposed. Through introducing the concept of mutational deterioration (MD) and developing a theoretical formalism on MD minimization we have proved: 1, the redundancy distribution of codons in the genetic code obeys MD minimization principle; 2, the hydrophilic-hydrophobic distribution of amino acids on the code table is global MD (GMD) minimal; 3, the standard genetic code can be deduced from the adaptive minimization of GMD; 4, the variants of the standard genetic code can be explained quantitatively by use of GMD formalism and the general trend of the evolution is GMD non-increasing which reflects the selection on the code. We have demonstrated that the redundancy distribution of codons and the hydrophobic-hydrophilic (H-P) distribution of amino acids are robust in the code relative to the mutational parameter, and indicated that the GMD can be looked as a non-fitness function on the adaptive landscape. Finally, an important aspect on the symmetry of the code construction, the Yin-Yang duality is investigated. The Yin-Yang duality among codons affords a sound basis for understanding the H-P structure in the genetic code.
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PDF链接：
https://arxiv.org/pdf/0908.3067