摘要翻译：
细胞色素P450是药物代谢和其他相关过程的基础蛋白。通过结合文本挖掘和网络分析的P450文献，我们绘制了生物医学研究社区的出现和演变，致力于这一家族的蛋白质。我们的研究结果表明，研究P450的历史进程主要围绕药物诱导动物肝微粒体P450、P450酶的化学抑制剂在体外代谢研究中的应用以及大肠杆菌表达系统的发展等方法学成就而展开。我们找到了明确的证据，证明P450研究确实构成了一种物质科学文化，正如我们在文中所讨论的那样。
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英文标题：
《The evolution and structure of biomedical knowledge on cytochrome P450》
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作者：
David Fajardo-Ortiz, Miguel Lara, and Victor M. Castano
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最新提交年份：
2017
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Cytochrome P450 are fundamental proteins to the metabolism of drugs and other relevant processes. through a combination of text mining and network analysis of the P450 literature we mapped the emergence and evolution of the biomedical research communities working on this family of proteins. Our results suggest that the historical research communities that worked on P450 emerged and were organized mainly around methodological achievements like the induction of animal liver microsomal P450 by drugs, the use of chemical inhibitors of P450 enzymes in in-vitro metabolism studies and the development of E. coli expression systems. We found clear evidence that P450 research indeed constitutes a material scientific culture, as we discuss in the text.
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PDF链接：
https://arxiv.org/pdf/1711.10009