摘要翻译：
过氧化物和超氧化物的产生是有氧代谢的必然结果，虽然这些特殊的“活性氧物种”（ROSs）可以表现出许多生物学效应，但它们本身并不具有过度的反应性，因此在生理浓度下它们并不特别有害。然而，它们与配体很差的铁物种的反应会导致催化产生非常反应性和危险的羟基自由基，这是特别有害的，也是慢性炎症的主要原因。我们回顾了大量和广泛的证据，这些证据表明（su）过氧化物和连接不良的铁的结合参与了大量的生理和病理过程和炎症疾病，特别是涉及细胞和器官性能的进行性退化。这些疾病有许多相似之处，因此可以认为有一个共同的原因（即铁催化的自由基，特别是羟自由基的产生）。回顾的研究包括那些专注于一系列心血管、代谢和神经疾病的研究，在这些疾病中，铁可以在斑块和病变的部位找到，以及表明铁对衰老和长寿的重要性的研究。因此，天然或合成配体对铁的有效螯合具有重要的生理（和潜在的治疗）重要性。作为系统的性质，我们需要认识到生理可观察到的现象有多种分子原因，当多种因素同时结合时，孤立地研究它们会导致不一致的明显因果关系模式。例如，这解释了已经观察到的抗氧化剂的明显混合效应，等等。
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英文标题：
《Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor
  to the Aetiology of Vascular and Other Progressive Inflammatory and
  Degenerative Diseases》
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作者：
Douglas B. Kell
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最新提交年份：
2008
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...
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PDF链接：
https://arxiv.org/pdf/0808.1371