摘要翻译：
Huxley和Simmons之后的经典模型的基石是假设肌球蛋白头只能存在于几个离散的状态，并且不规则地从一个状态跳到另一个状态。尽管证实或驳斥离散态的存在对于解决肌球蛋白运动问题至关重要，但迄今为止，还没有找到一种实验验证这一假设的方法。在这里，我展示了一组等长的肌球蛋白头沿着肌动蛋白丝等距离排列产生的X线模式，这种模式随构象类型的不同而变化。如果所有肌球蛋白头的杠杆臂位于一个相同的位置（连续构象），则所有肌球蛋白头具有相同的形状因子，并且均匀地散射电磁波。在这种情况下，只有与头部的空间顺序相关联的几何因素将决定X射线模式。如果杠杆臂的平均位置相同，情况就会改变，但本质上每个头只能处于几个不同的离散状态，从一个不规则地跳到另一个。在这种情况下，不同状态对应的形状因子是不同的，不同磁头散射的X射线相位增量也是不同的。由于每一个辐射量子都与处于不同状态的磁头相互作用，这就导致了额外的干涉，与连续型构象的磁头相比，X射线图形中的某些峰会减弱甚至消失。本文对描述这两种情况的公式进行了比较。一般来说，X射线模式之间的区别并不明显，但在构象过程的某些阶段，它们可能会有明显的不同（各个杠杆臂的位置取决于离散模型的类型）。因此，幸运的是，人们可以尝试使用高灵敏度的设备来找出这种差异。
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英文标题：
《X-ray experiment provides a way to reveal the distinction between
  discrete and continuous conformation of myosin head》
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作者：
E. V. Rosenfeld
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最新提交年份：
2016
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  The corner stone of the classical model after Huxley and Simmons is supposition that a myosin head can reside only in several discrete states and irregularly jumps from one state to another. Until now, it has not been found a way to experimentally verify this supposition although confirmation or refutation of the existence of discrete states is crucial for the solution of myosin motor problem. Here I show that a set of equal myosin heads arranged equidistantly along an actin filament produce X-ray pattern which varies with the type of conformation. If the lever arms of all myosin heads reside in one and the same position (continuous conformation), all the heads have the same form-factor and equally scatter electromagnetic wave. In this case, only the geometric factor associated with a spatial ordering of the heads will determine the X-ray pattern. The situation changes if the average lever arm position is the same, but inherently every head can reside only in several diverse discrete states, hopping irregularly from one to another. In this case, the form-factors corresponding to distinct states are dissimilar, and the increments in phases of X-rays scattered by different heads are different as well. Inasmuch as every quantum of radiation interacts with the heads residing in different states, this results in additional interference and some peaks in the X-ray pattern should slacken or even extinct as compared with the pattern from the heads with the continuous-type conformation. The formulas describing both cases are compared in this article. In general, the distinction between X-ray patterns is insignificant, but they could be appreciably different at some stages of conformation process (respective lever arm position depends on the type of discrete model). Consequently, one can with luck attempt to find out this difference using a high-sensitive equipment.
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PDF链接：
https://arxiv.org/pdf/1602.08913