摘要翻译：
背景：社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）是近年来出现的一种新型耐甲氧西林金黄色葡萄球菌，并在社区迅速传播。医院获得性耐甲氧西林金黄色葡萄球菌（HA-MRSA）的替代品侵入医院环境也有记录。CA-MRSA和HA-MRSA的共定植将具有重要的临床意义，因为抗菌药物敏感性分布的差异和遗传信息交换的潜力。方法：建立一个确定的数学模型来描述HA-MRSA和CA-MRSA在医院环境中的传播动力学，并量化两者共定植的出现。结果：模型分析表明，随着时间的推移，共定植状态成为地方病，并且没有竞争排斥任何一个菌株。在CA-MRSA定植患者中，增加住院时间或住院率会导致共定植状态的快速增加。与耐甲氧西林金黄色葡萄球菌非殖民化策略相比，提高手卫生依从性对降低HA-MRSA、CA-MRSA患病率和共殖民化状态的影响最大。结论：该模型预测，随着CA-MRSA群体宿主的不断扩大，大多数住院患者将同时感染CA-MRSA和HA-MRSA。
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英文标题：
《Rapid emergence of co-colonization with community-acquired and
  hospital-acquired methicillin-resistant Staphylococcus aureus strains in the
  hospital setting》
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作者：
Erika M. C. D'Agata, Glenn F. Webb, and Joanna Pressley
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最新提交年份：
2009
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Populations and Evolution        种群与进化
分类描述：Population dynamics, spatio-temporal and epidemiological models, dynamic speciation, co-evolution, biodiversity, foodwebs, aging; molecular evolution and phylogeny; directed evolution; origin of life
种群动力学；时空和流行病学模型；动态物种形成；协同进化；生物多样性；食物网；老龄化；分子进化和系统发育；定向进化；生命起源
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一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Background: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), a novel strain of MRSA, has recently emerged and rapidly spread in the community. Invasion into the hospital setting with replacement of the hospital-acquired MRSA (HA-MRSA) has also been documented. Co-colonization with both CA-MRSA and HA-MRSA would have important clinical implications given differences in antimicrobial susceptibility profiles and the potential for exchange of genetic information.   Methods: A deterministic mathematical model was developed to characterize the transmission dynamics of HA-MRSA and CA-MRSA in the hospital setting and to quantify the emergence of co-colonization with both strains.   Results: The model analysis shows that the state of co-colonization becomes endemic over time and that there is no competitive exclusion of either strain. Increasing the length of stay or rate of hospital entry among patients colonized with CA-MRSA leads to a rapid increase in the co-colonized state. Compared to MRSA decolonization strategy, improving hand hygiene compliance has the greatest impact on decreasing the prevalence of HA-MRSA, CA-MRSA and the co-colonized state.   Conclusions: The model predicts that with the expanding community reservoir of CA-MRSA, the majority of hospitalized patients will become colonized with both CA-MRSA and HA-MRSA.
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PDF链接：
https://arxiv.org/pdf/0906.3319