摘要翻译:
在胃肠道(GI)的运动功能中,肌肉循环和纵向运动的协调是至关重要的。肠壁运动依赖于肠壁平滑肌层的肌源性活动特性,这是对扩张做出反应的主动收缩力的能力。将环行平滑肌和纵行平滑肌中的应力看作是被动的(取决于肌肉变形)和主动的(取决于肌张力)分量的总和,并假定肌张力的变化取决于当前的应力-应变条件,得到了将肠段充盈-排空周期描述为肠壁环行肌和纵行肌协调活动的四常微分方程组(ODE)。建立模型条件的一般方法是基于前面描述的模型,仅限于恒定长度的循环扩张储层。结果表明,两个正交肌层的协调活动是相互一致变化模式的交替阶段,如壁的伸展和肌张力。这些结果也有助于对Auerbach和Meisner的肌间神经丛和黏膜下神经丛在调节肠自主运动中的作用的现有认识,以及阐明Cajal间质细胞(ICC)触发平滑肌收缩的功能机制。
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英文标题:
《The model of circular and longitudinal smooth muscle motions in the
motility of intestinal segment》
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作者:
Garri Davydyan
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最新提交年份:
2014
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
Coordination in circular and longitudinal muscle motions are of crucial importance in the motor function of gastrointestinal (GI) tract. Intestinal wall motions depend on myogenic-active properties of smooth muscles layers of intestinal wall, which is the ability to create active contractile forces in response to distension. Considering the stress in the circular and longitudinal smooth muscles as a sum of passive, depending on muscle deformations, and active, depending on muscle tone, components, and also assuming that the change in the muscle tone depends on the current stress-strain condition, the system of four ordinary differential equations (ODE) is obtained, which describes filling-emptying cycle of intestinal segment as a process of coordinated activities of circular and longitudinal muscles of intestinal wall. A general approach in formulating the modelling conditions is based on the previously described model restricted to the circularly distensible reservoir of constant length. Obtained results illustrate the character of coordinated activities of two orthogonal muscle layers, which are alternating phases of reciprocally and uniformly changing modalities such as stretching of the wall and muscle tone. The results also contribute to the existing understanding of the roles of Auerbach's and Meisner's intermuscular and submucous neural plexuses in regulations of autonomous intestinal motility, as well as clarify functional mechanisms of the interstitial cells of Cajal (ICC) in triggering of smooth muscle contractions.
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PDF链接:
https://arxiv.org/pdf/1406.6604