摘要翻译：
在真核基因中，蛋白质的编码序列被分裂成几个片段，外显子，由非编码DNA延伸分离，内含子。原核生物的基因组中没有内含子。我们报告了在动物、植物和真菌王国中的各种生物的肌动蛋白基因的稳定性域的计算。之所以选择肌动蛋白基因，是因为它们在进化过程中高度保守。在这些基因中，所有内含子都被移除，以模仿真核生物早期发育时的古老基因，即在内含子插入之前。在进化的远缘生物中发现了共同的稳定边界，这意味着这些边界可以追溯到真核生物的早期起源。一般来说，在脊椎动物和其他动物的内含子位置与内含子的边界相对应，而在植物和真菌的内含子位置相对应。最清晰的边界是在真菌、藻类和动物的内含子位于仅隔一个核苷酸的位置上的位点，这确定了插入的热点。这些结果表明，一些内含子可能是通过热力学驱动机制结合到基因组中的，这与以前对人类基因的观察一致。他们还提出了植物和动物内含子插入的不同机制。
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英文标题：
《Stability domains of actin genes and genomic evolution》
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作者：
E. Carlon, A. Dkhissi, M. Lejard Malki, R. Blossey
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最新提交年份：
2007
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Biomolecules        生物分子
分类描述：DNA, RNA, proteins, lipids, etc.; molecular structures and folding kinetics; molecular interactions; single-molecule manipulation.
DNA、RNA、蛋白质、脂类等；分子结构与折叠动力学；分子相互作用；单分子操作。
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一级分类：Physics        物理学
二级分类：Statistical Mechanics        统计力学
分类描述：Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变，热力学，场论，非平衡现象，重整化群和标度，可积模型，湍流
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一级分类：Physics        物理学
二级分类：Biological Physics        生物物理学
分类描述：Molecular biophysics, cellular biophysics, neurological biophysics, membrane biophysics, single-molecule biophysics, ecological biophysics, quantum phenomena in biological systems (quantum biophysics), theoretical biophysics, molecular dynamics/modeling and simulation, game theory, biomechanics, bioinformatics, microorganisms, virology, evolution, biophysical methods.
分子生物物理、细胞生物物理、神经生物物理、膜生物物理、单分子生物物理、生态生物物理、生物系统中的量子现象（量子生物物理）、理论生物物理、分子动力学/建模与模拟、博弈论、生物力学、生物信息学、微生物、病毒学、进化论、生物物理方法。
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一级分类：Quantitative Biology        数量生物学
二级分类：Populations and Evolution        种群与进化
分类描述：Population dynamics, spatio-temporal and epidemiological models, dynamic speciation, co-evolution, biodiversity, foodwebs, aging; molecular evolution and phylogeny; directed evolution; origin of life
种群动力学；时空和流行病学模型；动态物种形成；协同进化；生物多样性；食物网；老龄化；分子进化和系统发育；定向进化；生命起源
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英文摘要：
  In eukaryotic genes the protein coding sequence is split into several fragments, the exons, separated by non-coding DNA stretches, the introns. Prokaryotes do not have introns in their genome. We report the calculations of stability domains of actin genes for various organisms in the animal, plant and fungi kingdoms. Actin genes have been chosen because they have been highly conserved during evolution. In these genes all introns were removed so as to mimic ancient genes at the time of the early eukaryotic development, i.e. before introns insertion. Common stability boundaries are found in evolutionary distant organisms, which implies that these boundaries date from the early origin of eukaryotes. In general boundaries correspond with introns positions of vertebrates and other animals actins, but not much for plants and fungi. The sharpest boundary is found in a locus where fungi, algae and animals have introns in positions separated by one nucleotide only, which identifies a hot-spot for insertion. These results suggest that some introns may have been incorporated into the genomes through a thermodynamic driven mechanism, in agreement with previous observations on human genes. They also suggest a different mechanism for introns insertion in plants and animals.
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PDF链接：
https://arxiv.org/pdf/710.1025